Well, I'm probably not the best person to answer your question (not my area of expertise), but I own an LTD mh-50, It's a rather low-end guitar in comparison to alot of the models out there... But if this is low-end, I'd love to try out a more expensive LTD/ESP guitar. The mh-50 sounds great for what it is, and it feels incredible... Very natural to play.
I haven't tried the higher-end LTDs, but if they retain the same sound/feel as this one and merely improve on it, I wouldn't be able to reccomend them enough.

Can't say for certain though, so don't take my word for it.
Was there a specific comparison you were wondering about, eg. what kind of wood or neck joint to go with? Or just wondering if there was much difference in general?